All Publications
2026
Rifai O.M., Waldron F.M., O'Shaughnessy J., Read F.L., Gilodi M., Pastore A., Shneider N.A., Tartaglia G.G., Zacco E., Spence H., Gregory J.M.
Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis
Brain Communications, vol. 8, (no. 2)
Article
Journal
2026
Milordini G., Zacco E., Masi M., Armaos A., Di Palma F., Oneto M., Gilodi M., Rupert J., Broglia L., Varignani G., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction impair homologous recombination and induce synthetic lethality
Nature Communications, vol. 17, (no. 1)
Article
Journal
2025
Intze A., Temperini M.E., Rupert J., Polito R., Veber A., Puskar L., Schade U., Ortolani M., Zacco E., Tartaglia G.G., Giliberti V.
Effect of RNA on the supramolecular architecture of α-synuclein fibrils
Biophysical Journal
2024
Spence H., Waldron F.M., Saleeb R.S., Brown A.-L., Rifai O.M., Gilodi M., Read F., Roberts K., Milne G., Wilkinson D., O'Shaughnessy J., Pastore A., Fratta P., Shneider N., Tartaglia G.G., Zacco E., Horrocks M.H., Gregory J.M.
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Acta Neuropathologica, vol. 147, (no. 1)
2024
Zacco E., Broglia L., Kurihara M., Pastore A., Gustincich S., Plath K., Nagakawa S., Cerase A., Sanchez de Groot N., Tartaglia G.G.
RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding
Chemical Reviews
Scientific Talks
2022
Zacco E.
Amino acid-glycan conjugates as protein aggregation inhibitors: A spoonful of sugar against proteinopathies
Neuroglycoprotein in health and disease
Workshop/Symposium
2022
Zacco E.
“Out of phase”: A tale of proteins and RNA in biological condensation
Universita degli Studi di Milano - Bicocca
Institute
2021
Zacco E.
Exploring early events in protein phase separation with RNA aptamers
Institut de Neurociencies, Universitat Autonoma de Barcelona
Institute
2021
Zacco E.
Exploring early events in protein phase separation with RNA aptamers
Universita degli Studi di Roma La Sapienza
Institute
2021
Zacco E.
Exploring protein phase separation in living cells with RNA aptamers
AGI2021
Conference
Awards and Achievements
2025
Milordini G., Zacco E., Armaos A., Di Palma F., Masi M., Gilodi M., Rupert J., Broglia L., Varignani G., Oneto M., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment, advancing synthetic lethality in cancer therapy
2024
Milordini G., Zacco E., Armaos A., Di Palma F., Masi M., Gilodi M., Rupert J., Broglia L., Varignani G., Oneto M., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment, advancing synthetic lethality in cancer therapy
2023
Tartaglia G., Zacco E.
Target ALS grant
2023
Milordini G., Armaos A., Broglia L., Zacco E., Girotto S., Tartaglia G.G., Cavalli A.
Targeting the RAD51-BRCA2 interaction: aptamers as potential modulators of homologous recombination in cancer cells
2022
Zacco E., Tartaglia GG., Horrocks M., Gregory J., Schneider N.
Probing RNA-binding protein aggregates at the nanoscale using in-silico-designed aptamers.
Editorships
2021
Zacco E.
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics
2019
Zacco E.
Protein and RNA Networks and Biology, section of Frontiers in Molecular Biosciences
2018
Zacco E.
Protein Misfolding in Ageing and Neurodegeneration, research topic in Frontienrs in Molecular Bioscience
Organized Events
2018
Zacco E., Pastore A.
Protein misfolding in ageing and neurodegeneration: from basic biology to drug development